Přírodovědecká fakulta
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Kvalifikační práce [20340]
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Kvalifikační práce obhajované před rokem 2006 [0]
Theses defended before year 2006
Recent Submissions
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Early evolution of land plants in the Silurian with special respect to the Prague Basin (Barrandian area, Czech Republic)
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 26. 3. 2025This dissertation focuses on the study of fossil evidence of terrestrial plants from the Silurian period, found in the sediments of the Prague Basin - a site of global significance for documenting the evolution of early ... -
Genomická architektura a molekulární mechanismy hybridní sterility myši.
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2021)Date of defense: 11. 2. 2021Hybrid sterility is one of the reproductive isolation mechanisms restricting gene flow between the related species and leading to speciation. PR domain containing 9 (Prdm9), the only known vertebrate hybrid sterility gene, ... -
The effect of thermogenic stimuli on the immune system
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 25. 3. 2025Organisms possess sophisticated defense mechanisms to maintain homeostasis and combat threats. The immune system plays a pivotal role in this defense, recognizing and responding to threats from both the internal and external ... -
Joseph Bernt v kontextu utváření Staatsarzneikunde
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 25. 3. 2025The presented dissertation focuses on two interconnected topics. First, it examines Joseph Bernt (1770-1842), a native of Litoměřice and a professor of so-called state medicine, who served at both the Vienna and Prague ... -
Maintenance of genome integrity in early development, aging and diseases
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 24. 3. 2025Maintenance of genome integrity includes different pathways, such as control of the cell cycle, checkpoint signaling, and DNA repair pathways, which are essential for normal cell division, healthy aging of organisms, and ... -
Analýza střevní mikrobioty v různých částech trávicího traktu u vybraných zástupců rodu Mus z pohledu životního stylu, genetické příbuznosti a sociálních vztahů
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 24. 3. 2025The vertebrate gastrointestinal microbiota (GM) affects host health, physiology, and shapes sig- nificantly its host's phenotype, including fitness-related traits. Conversely, GM composition is shaped by host genetics, but ... -
Učitelské strategie rozvoje mapových dovedností ve výuce zeměpisu
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 24. 3. 2025Developing map skills is a key part of geography education as it enables students to better understand spatial relationships and to analyse or interpret geographical information. This dissertation focuses on teachers' ... -
Predictors and correlates of altruism in humans from the evolutionary viewpoint
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 24. 3. 2025Predictors and correlates of altruism in humans from the evolutionary viewpoint Julie Nekola Nováková ABSTRACT Altruism has long presented an evolutionary enigma, as this behavior - where an individual helps another at its ... -
Pořadí narození jako faktor ovlivňující člověka
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 24. 3. 20251 Abstract Birth order plays a significant role in individual development, influencing personality traits, educational achievements, and reproductive strategies. This dissertation examines sibling positions within family ... -
New deazapurine nucleobases, nucleosides and nucleotides as potential cytostatics or CD73 inhibitors
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 21. 3. 20251 ABSTRACT This thesis aims to regulate the role of adenosine in various cancers by modulating the activity of two different molecular targets. In the first part of my thesis, I describe the synthesis of a larger library ... -
Characterization of LACTB-induced tumor suppressor pathway
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2024)Date of defense: 7. 6. 2024(English) Tumor suppressors genes are capable of repressing the growth of neoplastic cells; therefore, their inactivation is an important hallmark of cancer. The novel tumor suppressor Serine beta-lactamase-like protein ... -
Mitochondrial respiratory complex II and its function in cancer
Defence status: RECOGNIZED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 3. 4. 20251 Abstract Mitochondria are found in nearly all eukaryotic cells, serving as energy producers and key regulators of metabolic pathways, such as the tricarboxylic acid (TCA) cycle and oxidative phosphorylation (OXPHOS). ... -
Functional characterization of the type III secretion system of the human pathogen Bordetella pertussis
Defence status: RECOGNIZED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 8. 4. 2025The type three secretion system (T3SS) was originally considered to be inactive in B. pertussis, but it was later described to be active in recent clinical isolates. Later, T3SS activity was observed also in highly passaged ... -
Molecular mechanisms of amoeboid invasion of cancer cells
Defence status: RECOGNIZED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 20. 3. 2025Tumour cell invasion is one of the most critical steps in malignant progression. It includes a broad spectrum of mechanisms, including both individual and collective cell migration, which enables them to spread towards ... -
Český volič: vybrané aspekty rozhodování voličů v typově odlišných regionech
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 19. 3. 2025The voter is not an isolated individual but a part of a complex system where their decision- making is significantly influenced by the spatial context of the locality in which they live, across different levels from the ... -
Studium diferenciačního potenciálu Sertoliho kmenových buněk Xenopus tropicalis in vitro.
Defence status: RECOGNIZED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 1. 4. 2025Sertoli cells are somatic cells of the testis with fascinating properties and a wide range of functions. In addition to forming the structure of the seminiferous tubules and the hematotesticular barrier, they control male ... -
Habitat requirements in Orthoptera - ecological, physiological and evolutionary factors
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 14. 3. 2025Orthopterans play a vital role in grassland ecosystems in Central Europe. Species within this order inhabit a wide range of habitats, including microclimatic extremes such as rocky steppes, sand dunes, or conversely cold ... -
Potravní vztahy a strategie ve hmyzích společenstvech na mršinách.
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 14. 3. 2025Carcasses, as one of the ephemeral habitats, represent an energy-rich but time- limited food resource. As a result, individual necrobiotic insect species are under strong competitive pressure. Using targeted manipulation ... -
Buněčné a molekulární mechanizmy regulace TRPC5 receptoru
Defence status: RECOGNIZED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 27. 3. 2025The TRPC5 ion channel is a molecular cold detector involved in the development of neuro- pathic and inflammatory pain in the peripheral nervous system. Its possible involvement in the mechanisms of the development of cold ... -
Optimization of conditions and SERS spectral monitoring of biological important molecules
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 12. 3. 2025Quantifying the drug concentration in plasma samples from treated patients is crucial for precisely adjusting their treatment. Before introducing a new procedure for determining the level of a substance in blood plasma (in ...
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