Kvalifikační práce
Procházet dle
Poslední příspěvky
Zobrazují se záznamy 1-10 z 20330
-
New deazapurine nucleobases, nucleosides and nucleotides as potential cytostatics or CD73 inhibitors
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2025)Datum obhajoby: 21. 3. 20251 ABSTRACT This thesis aims to regulate the role of adenosine in various cancers by modulating the activity of two different molecular targets. In the first part of my thesis, I describe the synthesis of a larger library ... -
Characterization of LACTB-induced tumor suppressor pathway
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2024)Datum obhajoby: 7. 6. 2024(English) Tumor suppressors genes are capable of repressing the growth of neoplastic cells; therefore, their inactivation is an important hallmark of cancer. The novel tumor suppressor Serine beta-lactamase-like protein ... -
Mitochondrial respiratory complex II and its function in cancer
Výsledek obhajoby: UZNÁNO(Univerzita Karlova, Přírodovědecká fakulta, 2025)Datum obhajoby: 3. 4. 20251 Abstract Mitochondria are found in nearly all eukaryotic cells, serving as energy producers and key regulators of metabolic pathways, such as the tricarboxylic acid (TCA) cycle and oxidative phosphorylation (OXPHOS). ... -
Functional characterization of the type III secretion system of the human pathogen Bordetella pertussis
Výsledek obhajoby: UZNÁNO(Univerzita Karlova, Přírodovědecká fakulta, 2025)Datum obhajoby: 8. 4. 2025The type three secretion system (T3SS) was originally considered to be inactive in B. pertussis, but it was later described to be active in recent clinical isolates. Later, T3SS activity was observed also in highly passaged ... -
Molecular mechanisms of amoeboid invasion of cancer cells
Výsledek obhajoby: UZNÁNO(Univerzita Karlova, Přírodovědecká fakulta, 2025)Datum obhajoby: 20. 3. 2025Tumour cell invasion is one of the most critical steps in malignant progression. It includes a broad spectrum of mechanisms, including both individual and collective cell migration, which enables them to spread towards ... -
Český volič: vybrané aspekty rozhodování voličů v typově odlišných regionech
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2025)Datum obhajoby: 19. 3. 2025The voter is not an isolated individual but a part of a complex system where their decision- making is significantly influenced by the spatial context of the locality in which they live, across different levels from the ... -
Studium diferenciačního potenciálu Sertoliho kmenových buněk Xenopus tropicalis in vitro.
Výsledek obhajoby: UZNÁNO(Univerzita Karlova, Přírodovědecká fakulta, 2025)Datum obhajoby: 1. 4. 2025Sertoli cells are somatic cells of the testis with fascinating properties and a wide range of functions. In addition to forming the structure of the seminiferous tubules and the hematotesticular barrier, they control male ... -
Habitat requirements in Orthoptera - ecological, physiological and evolutionary factors
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2025)Datum obhajoby: 14. 3. 2025Orthopterans play a vital role in grassland ecosystems in Central Europe. Species within this order inhabit a wide range of habitats, including microclimatic extremes such as rocky steppes, sand dunes, or conversely cold ... -
Potravní vztahy a strategie ve hmyzích společenstvech na mršinách.
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2025)Datum obhajoby: 14. 3. 2025Carcasses, as one of the ephemeral habitats, represent an energy-rich but time- limited food resource. As a result, individual necrobiotic insect species are under strong competitive pressure. Using targeted manipulation ... -
Buněčné a molekulární mechanizmy regulace TRPC5 receptoru
Výsledek obhajoby: UZNÁNO(Univerzita Karlova, Přírodovědecká fakulta, 2025)Datum obhajoby: 27. 3. 2025The TRPC5 ion channel is a molecular cold detector involved in the development of neuro- pathic and inflammatory pain in the peripheral nervous system. Its possible involvement in the mechanisms of the development of cold ...
RSS 1.0