Vážení uživatelé Digitálního repozitáře UK, z důvodu pravidelné údržby bude repozitář cca od 13:45 do 14:00 dočasně nedostupný. Uložte si prosím včas svoji práci a odhlaste s repozitáře. Děkujeme za pochopení. || Dear CU Digital Repository users, the repository will be temporarily unavailable due to the regular maintenance from approximately 13:45 PM to 14:00 PM. Please save your work in time and log out of the repository.
Kvalifikační práce
Browse by
Recent Submissions
Now showing items 1-10 of 20861
-
Transcriptomic profiling of the olfactory organs in mice.
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 17. 6. 2025Transcriptome studies are widely used to gain insights into tissue-specific biological processes. Although advances in sequencing technologies have greatly improved precision and throughput, the interpretation of read ... -
The relationship between codon volatility and selection
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 17. 6. 2025Codon volatility was proposed as a method to detect positive selection in the genome. It measures the probability that a single-nucleotide mutation in a codon will lead to a change in the encoded amino acid. This thesis ... -
Development of tools for analysis and interpretation of docking study results
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 17. 6. 2025Molecular docking is a widely used computational technique for predicting the preferred binding orientation and affinity of small molecules to protein targets. While docking programs such as AutoDock Vina provide ranked ... -
Decoding functional representations from population activity in V1 recorded during sleep
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 17. 6. 2025This thesis investigates whether spontaneous neural activity during sleep enables more stable decoding of orientation preference (OP) maps in the human primary visual cortex compared to wakefulness. Using intracortical ... -
Genetické příčiny periferních neuropatií a využití NGS a cloudových technologií v jejich diagnostice
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 17. 6. 2025Hereditary peripheral neuropathies represent a heterogeneous group of genetically determined diseases that significantly affect the function of the peripheral nervous system. The main clinical manifestations are slowly ... -
The Influence of Mutation Bias on Adaptive Evolution
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 17. 6. 2025Title: The Influence of Mutation Bias on Adaptive Evolution Author: Barbora Jasková Department: Department of Cell Biology Supervisor: Dr. Hana Rozhoňová Abstract: In evolutionary biology, natural selection acts upon genetic ... -
Inferring Phosphosite Functionality through Multi-Contextual Analysis
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 17. 6. 2025Phosphorylation, one of the most studied post-translational modifications, regulates a multitude of cellular processes by affecting protein function and structure in various ways, and functional characterization of ... -
Identifikace sekvenačních chyb v NGS vznikajících na podkladě sekvenčního kontextu, analytických postupů a mapovacích nástrojů
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 17. 6. 2025DNA sequencing represents a fundamental pillar ofmoderndiagnostics for current needs of molecular medicine. Although today's next-generation sequencing (NGS) technologies enable efficient reading of the entire humangenome, ... -
Identifikace nových indikací léčiv pomocí analýzy transkriptomu jednotlivých buněk
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 17. 6. 2025De novo drug development represents an exceedingly complex, time-consuming, and expensive process. Drug repurposing, utilizing large-scale transcriptomic datasets, has emerged as a promising alternative, accelerating the ... -
Alternative splicing analysis in single-cell RNA sequencing data
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 17. 6. 2025Ischemic brain injury initiates complex molecular responses in microglia, the resident immune cells of the brain. This thesis investigates whether alternative splicing patterns in mouse microglia change after ischemic ...
RSS 1.0