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Inferring Phosphosite Functionality through Multi-Contextual Analysis
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 17. 6. 2025Phosphorylation, one of the most studied post-translational modifications, regulates a multitude of cellular processes by affecting protein function and structure in various ways, and functional characterization of ... -
Identifikace sekvenačních chyb v NGS vznikajících na podkladě sekvenčního kontextu, analytických postupů a mapovacích nástrojů
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 17. 6. 2025DNA sequencing represents a fundamental pillar ofmoderndiagnostics for current needs of molecular medicine. Although today's next-generation sequencing (NGS) technologies enable efficient reading of the entire humangenome, ... -
Identifikace nových indikací léčiv pomocí analýzy transkriptomu jednotlivých buněk
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 17. 6. 2025De novo drug development represents an exceedingly complex, time-consuming, and expensive process. Drug repurposing, utilizing large-scale transcriptomic datasets, has emerged as a promising alternative, accelerating the ... -
Kontaminace potravin perfluorovanými a polyfluorovanými látkami
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 16. 6. 2025Perfluorinated and polyfluorinated substances (PFAS) form a group of anthropogenic compounds that contain a strong carbon-fluorine bond. Due to this bond, they exhibit high stability, which has been utilized in various ... -
Impact of snow reduction on decomposition and soil respiration
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 16. 6. 2025The global decline in snow cover affects biochemical processes in soil, potentially leading to changes in the carbon cycle. This thesis describes global and regional snow cover trends and summarizes current knowledge and ... -
Disturbance horských lesů vlivem lesního hospodaření a změn klimatu
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 16. 6. 2025In my work, I focused on describing the role of forest management and climate change on disturbances in montane temperate forests. Disturbances are an integral part of many ecosystems and play an important role in the ... -
Globální a lokální příčiny ohrožení oceánských druhů žraloků: role abiotických, biotických a antropogenních faktorů
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 16. 6. 2025Sharks, a key predators, play an important role in maintaining the balance of food webs and regulating the populations of other marine organisms. Despite this, their populations have declined drastically in recent decades. ... -
Ekologie rybích společenstev v okolí přehradních nádrží: struktura habitatů, migrace a potravní vztahy
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 16. 6. 2025Dams significantly disrupt natural river ecosystems and change the character of streams. They affect not only the phycical and chemical proprties of watercourses, but also the structure andcomposition of fish and invertebrate ... -
Význam ostrůvků neprodukčních biotopů pro ptáky v zemědělské krajině
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 16. 6. 2025Agricultural intensification and the associated loss of semi-natural habitats have contributed to a significant decline in biodiversity in agricultural areas in recent decades. Agricultural landscapes cover large areas in ... -
Theoretical Investigation of Zeolites Using NMR: From DFT to Machine Learning
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 16. 6. 2025Solid-state nuclear magnetic resonance (ssNMR) spectroscopy is a highly valuable tool for experimentally characterizing zeolites, due to its high sensitivity and the detailed structural insight it provides from the spectra. ...