Přírodovědecká fakulta
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GEOBIBLINE - Fulltexts [10555]
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Habilitační práce [85]
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Kvalifikační práce [20337]
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Kvalifikační práce obhajované před rokem 2006 [0]
Theses defended before year 2006
Recent Submissions
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Maintenance of genome integrity in early development, aging and diseases
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 24. 3. 2025Maintenance of genome integrity includes different pathways, such as control of the cell cycle, checkpoint signaling, and DNA repair pathways, which are essential for normal cell division, healthy aging of organisms, and ... -
Analýza střevní mikrobioty v různých částech trávicího traktu u vybraných zástupců rodu Mus z pohledu životního stylu, genetické příbuznosti a sociálních vztahů
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 24. 3. 2025The vertebrate gastrointestinal microbiota (GM) affects host health, physiology, and shapes sig- nificantly its host's phenotype, including fitness-related traits. Conversely, GM composition is shaped by host genetics, but ... -
Učitelské strategie rozvoje mapových dovedností ve výuce zeměpisu
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 24. 3. 2025Developing map skills is a key part of geography education as it enables students to better understand spatial relationships and to analyse or interpret geographical information. This dissertation focuses on teachers' ... -
Predictors and correlates of altruism in humans from the evolutionary viewpoint
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 24. 3. 2025Predictors and correlates of altruism in humans from the evolutionary viewpoint Julie Nekola Nováková ABSTRACT Altruism has long presented an evolutionary enigma, as this behavior - where an individual helps another at its ... -
Pořadí narození jako faktor ovlivňující člověka
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 24. 3. 20251 Abstract Birth order plays a significant role in individual development, influencing personality traits, educational achievements, and reproductive strategies. This dissertation examines sibling positions within family ... -
New deazapurine nucleobases, nucleosides and nucleotides as potential cytostatics or CD73 inhibitors
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 21. 3. 20251 ABSTRACT This thesis aims to regulate the role of adenosine in various cancers by modulating the activity of two different molecular targets. In the first part of my thesis, I describe the synthesis of a larger library ... -
Characterization of LACTB-induced tumor suppressor pathway
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2024)Date of defense: 7. 6. 2024(English) Tumor suppressors genes are capable of repressing the growth of neoplastic cells; therefore, their inactivation is an important hallmark of cancer. The novel tumor suppressor Serine beta-lactamase-like protein ... -
Mitochondrial respiratory complex II and its function in cancer
Defence status: RECOGNIZED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 3. 4. 20251 Abstract Mitochondria are found in nearly all eukaryotic cells, serving as energy producers and key regulators of metabolic pathways, such as the tricarboxylic acid (TCA) cycle and oxidative phosphorylation (OXPHOS). ... -
Functional characterization of the type III secretion system of the human pathogen Bordetella pertussis
Defence status: RECOGNIZED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 8. 4. 2025The type three secretion system (T3SS) was originally considered to be inactive in B. pertussis, but it was later described to be active in recent clinical isolates. Later, T3SS activity was observed also in highly passaged ... -
Molecular mechanisms of amoeboid invasion of cancer cells
Defence status: RECOGNIZED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 20. 3. 2025Tumour cell invasion is one of the most critical steps in malignant progression. It includes a broad spectrum of mechanisms, including both individual and collective cell migration, which enables them to spread towards ... -
Český volič: vybrané aspekty rozhodování voličů v typově odlišných regionech
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 19. 3. 2025The voter is not an isolated individual but a part of a complex system where their decision- making is significantly influenced by the spatial context of the locality in which they live, across different levels from the ... -
Studium diferenciačního potenciálu Sertoliho kmenových buněk Xenopus tropicalis in vitro.
Defence status: RECOGNIZED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 1. 4. 2025Sertoli cells are somatic cells of the testis with fascinating properties and a wide range of functions. In addition to forming the structure of the seminiferous tubules and the hematotesticular barrier, they control male ... -
Habitat requirements in Orthoptera - ecological, physiological and evolutionary factors
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 14. 3. 2025Orthopterans play a vital role in grassland ecosystems in Central Europe. Species within this order inhabit a wide range of habitats, including microclimatic extremes such as rocky steppes, sand dunes, or conversely cold ... -
Potravní vztahy a strategie ve hmyzích společenstvech na mršinách.
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 14. 3. 2025Carcasses, as one of the ephemeral habitats, represent an energy-rich but time- limited food resource. As a result, individual necrobiotic insect species are under strong competitive pressure. Using targeted manipulation ... -
Buněčné a molekulární mechanizmy regulace TRPC5 receptoru
Defence status: RECOGNIZED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 27. 3. 2025The TRPC5 ion channel is a molecular cold detector involved in the development of neuro- pathic and inflammatory pain in the peripheral nervous system. Its possible involvement in the mechanisms of the development of cold ... -
Optimization of conditions and SERS spectral monitoring of biological important molecules
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 12. 3. 2025Quantifying the drug concentration in plasma samples from treated patients is crucial for precisely adjusting their treatment. Before introducing a new procedure for determining the level of a substance in blood plasma (in ... -
Beyond dogmas in biology: revisiting calmodulin, galectin-1 and fibroblast growth factor II binding to membranes
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 12. 3. 2025Biologické membrány hrají klíčovou roli v buněčných procesech a slouží jako dynamické platformy pro regulaci aktivity a interakcí proteinů. Navzdory jejich ústřednímu postavení zůstávají některá dogmata o interakcích mezi ... -
Unraveling Nanoscale Membrane Organization of Gangliosides
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 12. 3. 2025Tato disertační práce se zaměřuje na to, jak změny v glykanové hlavové skupině gangliosidů ovlivňují jejich schopnost vytvářet nanoskopické domény v syntetických lipidových membránách. Gangliosidy jsou klíčovými složkami ... -
Ab initio molecular dynamics of photo-active organic molecules with non-adiabatic and spin-orbit effects.
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 12. 3. 2025of the Dissertation Wasif Baig, Mirza November 2024 Photosensitizers and fluorescent probes play a crucial role in photodynamic therapy and biochemistry. However, accurately simulating these molecules presents significant ... -
Modes of atmospheric circulation variability: comparison between datasets and temporal stability
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 12. 3. 2025Modes of interannual or interdecadal variability (i.e., teleconnections) represent anomalies in atmospheric circulation, each related to others on a scale of thousands of kilometres. These modes undergo spatial shifts ...
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