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Enzymová syntéza a studium vlastností DNA nesoucí elektron-donorní nebo elektron-akceptorní skupiny na nukleobázích
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 3. 6. 2025Modification of nucleic acids represents an important tool in modern bioorganic chemistry, enabling the expansion of their natural properties with new functional characteristics that can be utilized in structural studies. ... -
Charakterizace žíhaných borem dopovaných diamantových elektrod a jejich využití ke stanovení levamisolu
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 9. 6. 2025The aim of this work was to find the ideal conditions for determination of anthelmintic levamisole and its characterisation on boron-doped diamond (BDD) electrodes and comparison of levamisole behaviour on annealed and ... -
Pilotní studie genového expresního profilu karcinomu endometria
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 5. 6. 2025Endometrial carcinomas are the most common malignancy of the female population worldwide with their incidence steadily rising in the previous years. Compared to other gynecaological carcinomas, endometrial carcinoma has ... -
Strukturní analýza a inhibice karbonických anhydras patogenních kvasinek rodu Candida
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 5. 6. 2025This bachelor's thesis focuses on the study of the β-carbonic anhydrase CpNce103p from the pathogenic yeast Candida parapsilosis. The research was conducted as part of a long-term project in the laboratory of the Institute ... -
Tin in hydrogenation catalysis
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 6. 6. 2025This thesis investigates hexa-coordinated tin(IV) and tetra-coordinated tin(II) complexes as imine hydrogenation catalysts with molecular hydrogen as the reducing agent. Steric hindrance around the complexes prevents ... -
Studium organizace mitochondriálních superkomplexů a patomechanismů deficience komplexu III dýchacího řetězce
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 4. 6. 2025Mitochondria are complex semi-autonomous organelles that play a key role in the energy metabolism of the cell. Within the system of oxidative phosphorylation (OXPHOS), it ensures the production of ATP - a versatile and ... -
Syntéza nových kontrastních látek pro MRI na bázi kyseliny hyaluronové
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 10. 6. 2025The presented bachelor's thesis focuses on the chemical modification of hyaluronic acid with the aim of expanding its functional properties for magnetic resonance imaging. The importance stays on the functionalization of ... -
The development of a microfractionation method for plant extracts and subsequent antimicrobial screening
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 3. 6. 2025Bioaktivitou řízená frakcionace rostlinných extraktů je základem objevování rostlinných přírodních látek. Tento proces je bohužel zdlouhavý a těžkopádný: surové extrakty jsou frakcionovány, bioaktivita frakcí je testována, ... -
Jaká je funkce proteinu Het1p patogenní kvasinky Candida albicans?
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 3. 6. 2025Het1p is a protein found in pathogenic yeast Candida albicans. While this yeast has been widely studied, 66 % of its genes still has no clear evidence of their function, including Het1p. The role of this protein is associated ... -
Vysokoteplotní oxidace vysokoentropické slitiny AlTi0.5CrFeNi
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 5. 6. 2025This work concerns the study of the high-temperature oxidation of AlTi0,5CrFeNi high-entropy alloy at 800 řC, 900 řC and 1000 řC for 100 h and the understanding of this phenomenon. The thermodynamics of oxidation is examined ...
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