Endometrial carcinomas are the most common malignancy of the female population worldwide with their incidence steadily rising in the previous years. Compared to other gynecaological carcinomas, endometrial carcinoma has ...

This thesis investigates hexa-coordinated tin(IV) and tetra-coordinated tin(II) complexes as imine hydrogenation catalysts with molecular hydrogen as the reducing agent. Steric hindrance around the complexes prevents ...

The presented bachelor's thesis focuses on the chemical modification of hyaluronic acid with the aim of expanding its functional properties for magnetic resonance imaging. The importance stays on the functionalization of ...

Het1p is a protein found in pathogenic yeast Candida albicans. While this yeast has been widely studied, 66 % of its genes still has no clear evidence of their function, including Het1p. The role of this protein is associated ...

This bachelor's thesis dealt with indirect methods for detecting antibodies specific to early human papillomavirus (HPV) proteins. HPVs are most commonly transmitted sexually and cause a variety of benign and malignant ...

Mitochondrial diseases are a large group of disorders caused by nuclear or mitochon- drial DNA mutations. They are mainly caused by defects in the oxidative phosphory- lation system, which is the source of ATP for almost ...

This master's thesis investigated the development of a methodology for the speciation of inorganic antimony species, Sb(III) and Sb(V), employing atomic fluorescence spectrometry coupled with UV-photochemical vapor generation ...

This thesis focuses on the design, synthesis, and characterization of novel pyclen-based polydentate ligands with potential applications as chelators for radionuclides in the diagnosis and treatment of cancer. The work ...

Galectins are a group of soluble proteins that belong to the lectin family. These proteins play a crucial role in the binding of β-galactosides, modulating "cell-cell" and "cell-matrix" interactions, and participating in ...

The transcription factor p53 plays a key role in cell cycle arrest, DNA repair, apoptosis, tumor suppression, and maintainance of cellular homeostasis. Forkhead transcription factor O 4 (FOXO4) is also involved in controlling ...

In this master thesis, a voltammetric method was developed and partially validated for the determination of ibuprofen directly in a degradation cell. Conditions were optimized to enable the electrochemical degradation of ...

The thesis deals with the identification of thirteen historical remains of inorganic pharmaceuticals from the 18th century. The aim was to determine the composition of these pharmaceuticals, while only six samples have ...

Secondary chiral amines play a crucial role in modern chemistry, mainly in the synthesis of pharmaceuticals, where they function as building blocks, introducing chiral stereocenters or acting as ligands. These applications ...

The CD69 receptor, known as an early lymphocyte activation marker, is a surface protein expressed on activated leukocytes where it plays an important role in regulating the immune response. This receptor forms a disulfide-linked ...

The subject of this Thesis was the electrochemical study of 9-nitroanthracene (9-NA) on a glassy carbon electrode, finding the optimum conditions for determining this substance, and subsequently researching the interactions ...

Basic rocks undergoing eclogite facies metamorphism provide crucial insights into subduction zone development, especially concerning temperature and pressure conditions. Eclogites can preserve information about ultra-high-pressure ...

This diploma thesis deals with undetermined tetrapod fossils from the storage of the Chlupač Museum of Earth History. The fossils were collected in the area of the Ruhuhu basin (Tanzania) by the Czech-German geologist Ernst ...

Pharmaceutical compounds represent a significant source of environmental burden, and their presence in sewage sludge can limit the potential use of sludge in agriculture. This study focuses on optimizing the QuEChERS method ...

The aim of this thesis is to investigate how different forms of work influence parenting decisions. In particular, it focuses on flexible working hours and job stability as key factors that may influence childbearing ...

Understanding of protein structure (and molecular structure in general) plays a crucial role in the search for substances with specific applications - advanced materials, medicaments, etc. Computational chemistry and ...

Cytochrome P450 3A4 is the most abundant cytochrome in the human body. It plays a key role in the metabolism of xenobiotics, being involved in the metabolism of 30 to 50 % of all clinically used drugs. It also participates ...

Title: Synthesis of a Ferrocenylphosphine Bearing a Benzimidazole Substituent Author: Filip Šauli Department: Department of Inorganic Chemistry Supervisor: Prof. RNDr. Petr Štěpnička, Ph.D., DSc. Abstract: This bachelor's ...

This bachelor's thesis focuses on the relationship between selected tyrosine kinase inhibitors (TKIs) and the intestinal bacterium Escherichia coli, which is a natural component of the human microbiome. Five different ...

This thesis focuses on an innovative approach combining two high-throughput methods, DNA metabarcoding and bottom-up proteomic analysis, for the detection and identification of allergens in dust, including risk organisms. ...

The present bachelor's thesis focuses on analysing eleven red-figure vases from South Italy using a combination of elemental, phase, and imaging techniques. One of the objectives of this study was to examine the pottery ...

This Master's thesis focuses on the detailed study of Cretaceous conifer cones from the Czech Republic and Portugal. The material examined in this study originates from the Cenomanian-aged Peruc-Korycany Formation of the ...

Endohedral fullerenes are an intriguing and promising material for advanced contemporary applications, whether in solar panels, contrast compounds, or po- tentially quantum computing. As they are multi-atomic molecules, ...

Chitin is the second most abundant biopolymer in nature. Its derivatives chitosan and especially chitooligosaccharides exhibit a broad spectrum of biological activities with applications in biomedicine, agriculture, food ...

High-mountain plants had to develop various adaptations to survive in harsh conditions. While plant ecologists have been focusing on mountain regions for a long time, there is still not much known about adaptations of ...

Recent advances in computational neuroscience and machine learning have enabled increasingly sophisticated models of neuronal systems. How- ever, standard deep neural networks (DNNs) often prioritize task perfor- mance ...