Recent Submissions

Now showing items 1-10 of 20861

  • Transcriptomic profiling of the olfactory organs in mice. 

    Defence status: DEFENDED
    Grešš, Michal (Univerzita Karlova, Přírodovědecká fakulta, 2025)
    Date of defense: 17. 6. 2025
    Transcriptome studies are widely used to gain insights into tissue-specific biological processes. Although advances in sequencing technologies have greatly improved precision and throughput, the interpretation of read ...
  • The relationship between codon volatility and selection 

    Defence status: DEFENDED
    Kuniak, Adam (Univerzita Karlova, Přírodovědecká fakulta, 2025)
    Date of defense: 17. 6. 2025
    Codon volatility was proposed as a method to detect positive selection in the genome. It measures the probability that a single-nucleotide mutation in a codon will lead to a change in the encoded amino acid. This thesis ...
  • Development of tools for analysis and interpretation of docking study results 

    Defence status: DEFENDED
    Botková, Alexandra (Univerzita Karlova, Přírodovědecká fakulta, 2025)
    Date of defense: 17. 6. 2025
    Molecular docking is a widely used computational technique for predicting the preferred binding orientation and affinity of small molecules to protein targets. While docking programs such as AutoDock Vina provide ranked ...
  • Decoding functional representations from population activity in V1 recorded during sleep 

    Defence status: DEFENDED
    Jochman, Radoslav (Univerzita Karlova, Přírodovědecká fakulta, 2025)
    Date of defense: 17. 6. 2025
    This thesis investigates whether spontaneous neural activity during sleep enables more stable decoding of orientation preference (OP) maps in the human primary visual cortex compared to wakefulness. Using intracortical ...
  • Genetické příčiny periferních neuropatií a využití NGS a cloudových technologií v jejich diagnostice 

    Defence status: DEFENDED
    Horáková, Veronika (Univerzita Karlova, Přírodovědecká fakulta, 2025)
    Date of defense: 17. 6. 2025
    Hereditary peripheral neuropathies represent a heterogeneous group of genetically determined diseases that significantly affect the function of the peripheral nervous system. The main clinical manifestations are slowly ...
  • The Influence of Mutation Bias on Adaptive Evolution 

    Defence status: DEFENDED
    Jasková, Barbora (Univerzita Karlova, Přírodovědecká fakulta, 2025)
    Date of defense: 17. 6. 2025
    Title: The Influence of Mutation Bias on Adaptive Evolution Author: Barbora Jasková Department: Department of Cell Biology Supervisor: Dr. Hana Rozhoňová Abstract: In evolutionary biology, natural selection acts upon genetic ...
  • Inferring Phosphosite Functionality through Multi-Contextual Analysis 

    Defence status: DEFENDED
    Pulko, Ekaterina (Univerzita Karlova, Přírodovědecká fakulta, 2025)
    Date of defense: 17. 6. 2025
    Phosphorylation, one of the most studied post-translational modifications, regulates a multitude of cellular processes by affecting protein function and structure in various ways, and functional characterization of ...
  • Identifikace sekvenačních chyb v NGS vznikajících na podkladě sekvenčního kontextu, analytických postupů a mapovacích nástrojů 

    Defence status: DEFENDED
    Polák, Arnošt (Univerzita Karlova, Přírodovědecká fakulta, 2025)
    Date of defense: 17. 6. 2025
    DNA sequencing represents a fundamental pillar ofmoderndiagnostics for current needs of molecular medicine. Although today's next-generation sequencing (NGS) technologies enable efficient reading of the entire humangenome, ...
  • Identifikace nových indikací léčiv pomocí analýzy transkriptomu jednotlivých buněk 

    Defence status: DEFENDED
    Rýdlová, Magdaléna (Univerzita Karlova, Přírodovědecká fakulta, 2025)
    Date of defense: 17. 6. 2025
    De novo drug development represents an exceedingly complex, time-consuming, and expensive process. Drug repurposing, utilizing large-scale transcriptomic datasets, has emerged as a promising alternative, accelerating the ...
  • Alternative splicing analysis in single-cell RNA sequencing data 

    Defence status: DEFENDED
    Hanušová, Viktorie (Univerzita Karlova, Přírodovědecká fakulta, 2025)
    Date of defense: 17. 6. 2025
    Ischemic brain injury initiates complex molecular responses in microglia, the resident immune cells of the brain. This thesis investigates whether alternative splicing patterns in mouse microglia change after ischemic ...

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