Kvalifikační práce
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Transcriptomic profiling of the olfactory organs in mice.
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 17. 6. 2025Transcriptome studies are widely used to gain insights into tissue-specific biological processes. Although advances in sequencing technologies have greatly improved precision and throughput, the interpretation of read ... -
The relationship between codon volatility and selection
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 17. 6. 2025Codon volatility was proposed as a method to detect positive selection in the genome. It measures the probability that a single-nucleotide mutation in a codon will lead to a change in the encoded amino acid. This thesis ... -
Development of tools for analysis and interpretation of docking study results
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 17. 6. 2025Molecular docking is a widely used computational technique for predicting the preferred binding orientation and affinity of small molecules to protein targets. While docking programs such as AutoDock Vina provide ranked ... -
Decoding functional representations from population activity in V1 recorded during sleep
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 17. 6. 2025This thesis investigates whether spontaneous neural activity during sleep enables more stable decoding of orientation preference (OP) maps in the human primary visual cortex compared to wakefulness. Using intracortical ... -
Genetické příčiny periferních neuropatií a využití NGS a cloudových technologií v jejich diagnostice
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 17. 6. 2025Hereditary peripheral neuropathies represent a heterogeneous group of genetically determined diseases that significantly affect the function of the peripheral nervous system. The main clinical manifestations are slowly ... -
The Influence of Mutation Bias on Adaptive Evolution
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 17. 6. 2025Title: The Influence of Mutation Bias on Adaptive Evolution Author: Barbora Jasková Department: Department of Cell Biology Supervisor: Dr. Hana Rozhoňová Abstract: In evolutionary biology, natural selection acts upon genetic ... -
Inferring Phosphosite Functionality through Multi-Contextual Analysis
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 17. 6. 2025Phosphorylation, one of the most studied post-translational modifications, regulates a multitude of cellular processes by affecting protein function and structure in various ways, and functional characterization of ... -
Identifikace sekvenačních chyb v NGS vznikajících na podkladě sekvenčního kontextu, analytických postupů a mapovacích nástrojů
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 17. 6. 2025DNA sequencing represents a fundamental pillar ofmoderndiagnostics for current needs of molecular medicine. Although today's next-generation sequencing (NGS) technologies enable efficient reading of the entire humangenome, ... -
Identifikace nových indikací léčiv pomocí analýzy transkriptomu jednotlivých buněk
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 17. 6. 2025De novo drug development represents an exceedingly complex, time-consuming, and expensive process. Drug repurposing, utilizing large-scale transcriptomic datasets, has emerged as a promising alternative, accelerating the ... -
Alternative splicing analysis in single-cell RNA sequencing data
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 17. 6. 2025Ischemic brain injury initiates complex molecular responses in microglia, the resident immune cells of the brain. This thesis investigates whether alternative splicing patterns in mouse microglia change after ischemic ...
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