Experimental use of hydrogel implant for transscleral topotecan delivery for retinoblastoma treatment Abstract The thesis describes the testing of an episcleral bi-layered hydrogel implant for transscleral delivery of ...

Algorithm of personalised diagnostics and treatment in secondary prevention of ischemic stroke ABSTRACT Cerebrovascular diseases are the second most common cause of mortality and a significant cause of morbidity. Ischaemic ...

Study of binding partners and modulation of calmodulin functional properties and its fusion protein variants Abstract The thesis studies calmodulin (CaM)-dependent modulation of the TRPM ion channel subfamily involved in ...

Acute and chronic changes of the brain tissue and the extracellular space diffusion parameters in models of brain ischemia - the role of volume regulation of glia and AQP4/TRPV4 complex ABSTRACT The interaction of aquaporin ...

The 14-3-3 proteins are small regulatory biomolecules that are important for many important metabolic or signaling pathways. These conserved proteins were identified in all types of eukaryotic cells and they affect, for ...

EN Neuroblastoma (NBL) is a malignant embryonic tumor that originates from the peripheral nervous system. It is the most common solid extracranial tumor in children. The severity of neuroblastoma and the often unfavorable ...

This bachelor thesis explores the attitudes and motivations of paediatric nurses towards lifelong learning (with a focus on specialty education). The aim of the thesis is to use a questionnaire to explore the attitudes and ...

The influence of the physical and chemical properties of nanofibers on the modification of controlled delivery of bioactive substances in regenerative medicine. Abstract This work focuses on the assessment of the impact ...

Neurogenetic, biochemical and cognitive aspects of familial and sporadic forms of amyotrophic lateral sclerosis in the Czech population Abstract This thesis aims to highlight the pitfalls and risks of diagnosis and ...

Oncomarkers are an integral part of the diagnosis and treatment of prostate cancer. The introduction of prostate specific antigen (PSA) caused not only a detection of earlier stages of this disease. It is essential throughout ...

Chronic nephropathies in childhood are serious diseases with frequent progression of renal insufficiency to end-stage kidney disease requiring dialysis and/or kidney transplantation. The most common genetically determined ...

Type 1 diabetes (T1D) is chronic autoimmune process leading to progressive loss of beta cell of pancreas. Pathophysiological processes prior to clinical onset have not yet been elucidated and the prediabetic phase may ...

Summary: Staphylococcus aureus is the clinically most important species of the genus Staphylococcus. The bacterium is cause of broad spectrum of infections from benign skin infections to life threatening infections like ...

According the World Health Organization are cardiovascular diseases the main cause of death among adults in the Czech Republic, in 2013 their share was nearly 47%. They include deaths from coronary heart disease, stroke ...

Musculoskeletal tissues, bone and cartilage are under extensive investigation in tissue engineering research. A number of biodegradable and bioresorbable materials, as well as scaffold designs, have been experimentally ...

Probiotics are defined as live cultures of micro-organisms administered orally and acting beneficially on host health. They inf1uence favourably both development and stability of the microf1ora, inhibit colonization by ...

This bachelor thesis summarizes the findings on osteoarthritis of the medial compartment of the knee joint and explores its potential management through physiotherapy. The theoretical part presents knowledge about ...

The topic of this thesis was the mechanism of biomechanical and neurophysiological effects of joint mobilisations and manipulations, which we describe in the theoretical part. For better understanding of the issue we also ...

The bachelor's thesis deals with the issue of the risk of scoliosis in children after surgery for a congenital heart disease. The aim of the thesis is to process professional studies that have examined whether there is an ...

This bachelor thesis deals with the problem of poor posture and flat feet in preschool children and how to influence them through physiotherapy. The aim of the thesis was to develop a set of exercises for patients with ...

This thesis focused on demonstrating the connection between compression force and change in centre of gravity in standing. The theoretical part summarised the findings regarding motor control of leg and hand kinesiology, ...

Standardized tests in the paediatric population are a tool for physiotherapists to objectively assess the current state, the effect of therapy, as well as long-term monitoring of the patient. However, the results may be ...

The thesis focuses on the effect of the bicycle setup, specifically the handlebar height, on the upper trapezius muscle tension. The aim of the theoretical part was to summarize the existing knowledge about the influence ...

The thesis deals with the effect of physical therapy in patients with metabolic and premetabolic syndrome. The theoretical part aims to summarise the knowledge about metabolic syndrome, the etiology of its occurrence and ...

The aim of this thesis was to evaluate the prevalence, clinical aspects and therapeutic approaches of benign paroxysmal positional vertigo (BPPV) in the geriatric population. BPPV, as a common cause of vertigo, has a ...

This master thesis deals with the use of balance-strength training to influence dynamic stability in floorball players. The aim of this thesis was to determine whether players undergoing balance-strength training achieve ...