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Vplyv variant v génoch asociovaných s kancerogenézou na predispozíciu a fenotyp hereditárnych a sporadických nádorových ochorení gastrointestinálneho traktu
Defence status: DEFENDED(Univerzita Karlova, 2. lékařská fakulta, 2011)Date of defense: 20. 9. 2011This PhD. thesis deals with four different topics for which an increased risk of the development of colorectal cancer (CRC) is the common denominator. The first part is aimed to Cowden syndrome (CS), the second to Peutz-Jeghers ... -
Prostorové chování potkana v nestacionárních prostředích:úloha posteriorní parietální kůry
Defence status: DEFENDED(Univerzita Karlova, 2. lékařská fakulta, 2011)Date of defense: 19. 9. 2011Better understanding of cognitive functions and their underlying neural substrate requires appropriate behavioral testing methods. Studying spatial cognition of rat has taken advantage from plethora of tests examining ... -
Prostorové poznání v dynamických prostředích
Defence status: DEFENDED(Univerzita Karlova, 2. lékařská fakulta, 2011)Date of defense: 7. 3. 2011lnnate and acquired navigational abilities of animals are often used for purposes of study of neural mechanisms and modeling of cognitive functions. Detailed analysis of behavior allows Berger understanding of some brain ... -
Vazebné analýzy a charakterizování kandidátních genových lokusů a genů v rodinách s mnohočetným výskytem dědičné neuropatie Charcot-Marie-Tooth nebo časné hluchoty s neobjasněným genovým defektem
Defence status: DEFENDED(Univerzita Karlova, 2. lékařská fakulta, 2011)Date of defense: 13. 9. 2011Topics of the Ph.D. studies were: 1) hereditary neuropathy and 2) non-syndromic hearing loss Ad 1) The larger part of the dissertation thesis is devoted to hereditary neuropathies Charcot-Marie-Tooth (CMT). Four families ... -
Význam molekulárně genetických metod v diagnostice neuroinfekcí
Defence status: DEFENDED(Univerzita Karlova, 2. lékařská fakulta, 2016)Date of defense: 22. 3. 2016The role of molecular genetics methods in diagnostics of neuroinfections Background: Neuroinfections are serious diseases. They are associated with frequent development of permanent, debilitating consequences or even death. ... -
Preventivní a diagnostické metody u civilizačních chorob - význam suplementace vitaminem D
Defence status: DEFENDED(Univerzita Karlova, 2. lékařská fakulta, 2011)Date of defense: 30. 3. 2011Osteoporosis belongs between the most common civilization diseases. Insufficient vitamin D supplementation attributes to pathogenesis of the illness. Aim of the study was vitamin D levels monitorning in both healthy ... -
Genetické aspekty Crohnovy choroby
Defence status: DEFENDED(Univerzita Karlova, 2. lékařská fakulta, 2011)Date of defense: 21. 11. 2011Crohn's disease (CD) has been shown associated with the variants in NOD2, ATG16L1 and IL23R genes, in the IBD5 locus as well as in other genes involved in the immune response. The frequencies of the variants profoundly ... -
Analýza genů SH3TC2 a LMNA a klinická studie u českých pacientů a rodin s autozomálně recesívními typy dědičné neuropatie - Charcot-Marie-Tooth typ 1 a 2
Defence status: DEFENDED(Univerzita Karlova, 2. lékařská fakulta, 2011)Date of defense: 20. 6. 2011My PhD thesis can be devided into two parts: 1. Hereditary motor-sensory neuropathies (HMSN) 2. Selected muscle disorders The main emphasis was on the first part - hereditary motor and sensory neuropathies. Research was ... -
Clostridium difficile: Molekulární typizace klinicky významných izolátů
Defence status: DEFENDED(Univerzita Karlova, 2. lékařská fakulta, 2017)Date of defense: 2. 6. 2017Currently, Clostridium difficile is a leading nosocomial pathogen due to the spread of epidemic strains. Molecular typing of clinical isolates is an important part of C. difficile occurrence and spread control in hospitals ... -
Studium funkčních vlastností receptorů pro GABA a glycin v MNTB savců
Defence status: DEFENDED(Univerzita Karlova, 2. lékařská fakulta, 2017)Date of defense: 4. 9. 2017GABA and glycine are major inhibitory neurotransmitters in the central nervous system. They act on ionotropic and metabotropic receptors that form oligomeric complexes in plasma membrane of neuronal cells. Pharmacological ...
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