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Now showing items 111-120 of 20861
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Cα a Cβ zhrubené modely pro studium struktury funkčních materiálů založených na peptidech
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 5. 6. 2025Understanding of protein structure (and molecular structure in general) plays a crucial role in the search for substances with specific applications - advanced materials, medicaments, etc. Computational chemistry and ... -
Enzyme Kinetics of the HelD Protein
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 4. 6. 2025Mycobacterial HelD is a protein responsible for the dissociation of RNA polymerase from nucleic acids during stalled transcription. Subsequent release of HelD from RNAP can be achieved through ATP and GTP hydrolysis by ... -
Optimalizace přípravy rekombinantního CYP3A4
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 5. 6. 2025Cytochrome P450 3A4 is the most abundant cytochrome in the human body. It plays a key role in the metabolism of xenobiotics, being involved in the metabolism of 30 to 50 % of all clinically used drugs. It also participates ... -
Modelling of photocatalytic Cu2O surfaces with machine learning
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 3. 6. 2025Title: Modelling of photocatalytic Cu2O surfaces with machine learning Abstract: Cuprous oxide (Cu2O) absorbs light in a significant portion of the solar spectrum and prevents fouling organisms from growing. Moreover, this ... -
Syntéza ferrocenového fosfinu s benzimidazolovým substituentem
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 6. 6. 2025Title: Synthesis of a Ferrocenylphosphine Bearing a Benzimidazole Substituent Author: Filip Šauli Department: Department of Inorganic Chemistry Supervisor: Prof. RNDr. Petr Štěpnička, Ph.D., DSc. Abstract: This bachelor's ... -
Studium interakce placentární aromatasy s parfémy
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 5. 6. 2025Aromatase (CYP19A1, AROM) is a cytochrome P450 enzyme that catalyses the metabolic transformation of androgens into oestrogens by introducing an aromatic A-ring into these precursors. Disruption of its enzymatic function ... -
Vzájemný vliv tyrosinkinázových inhibitorů a bakterie E. coli
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 3. 6. 2025This bachelor's thesis focuses on the relationship between selected tyrosine kinase inhibitors (TKIs) and the intestinal bacterium Escherichia coli, which is a natural component of the human microbiome. Five different ... -
Identifikace nových zástupců hemových senzorových proteinů a jejich biochemická charakterizace
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 3. 6. 2025Hemoproteins represent a large class of proteins containing hem within their active site, that are involved in numerous essential biological processes, such as gas transport, redox reactions, enzymatic catalysis and cellular ... -
Využití DNA metabarkódování a proteomiky pro analýzu alergenů v prachu
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 4. 6. 2025This thesis focuses on an innovative approach combining two high-throughput methods, DNA metabarcoding and bottom-up proteomic analysis, for the detection and identification of allergens in dust, including risk organisms. ... -
Oxysteroly a jejich význam u gastrointestinálních tumorů
Defence status: DEFENDED(Univerzita Karlova, Přírodovědecká fakulta, 2025)Date of defense: 3. 6. 2025Oxysterols are oxidized forms of cholesterol, a lipid steroid alcohol present in the human body. Oxysterols are formed through the oxidation of cholesterol by enzymes or as a response to oxidative stress. These substances ...
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