Přírodovědecká fakulta: Poslední příspěvky
Zobrazují se záznamy 1-20 z 30988
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Hormonal and developmental regulation of sex-specific traits in squamate reptiles
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2025)Datum obhajoby: 28. 3. 2025The persistent puzzles of sexual dimorphism in reptiles - especially regarding sex-specific differences in body size, and male-typical traits such as behaviour and colouration - continue to intrigue researchers. This ... -
Úloha ARE5 ABCF proteinů v antibiotické rezistenci a regulaci u rodu Streptomyces
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2025)Datum obhajoby: 28. 3. 2025Microorganisms need to quickly adapt to environmental changes, which leads to optimization of their gene expression and its manifestation in various phenotypic traits. The dynamics and complexity of this plasticity are not ... -
Studium genetického pozadí solidních tumorů
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2025)Datum obhajoby: 28. 3. 2025Abstract The dissertation discusses different methodological approaches for detection of various genetic alterations in three types of solid tumors: thyroid, colorectal and pancreatic. Modern oncological research is based ... -
Bioinformatic evaluation of mass spectrometric data obtained by analysis of proteins modified by reactive oxygen species
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2025)Datum obhajoby: 28. 3. 2025The field of structural mass spectrometry (MS) is a rapidly developing area comprising of many versatile techniques for the characterisation of biomolecules under native or near-native conditions. Among them, reactive ... -
O původu organických aerosolů v ČR
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2025)Datum obhajoby: 28. 3. 2025The chemical composition of atmospheric aerosols (AA) has been shown to exert a significant influence on human health and atmospheric phenomena over the course of several decades. Consequently, there is a growing emphasis ... -
The occurrence of sunning clusters as a part of thermoregulation in red wood ants Formica polyctena
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2025)Datum obhajoby: 27. 3. 2025The occurrence of sunning clusters in red wood ants is a remarkable phenomenon and it is a ubiquitous behavior observed in all nests we studied. This specific behavior is supposed to play an important role in the nest ... -
Studium struktury a interakcí proteinů pomocí hmotnostní spektrometrie - vývoj metod a jejich aplikace.
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2025)Datum obhajoby: 28. 3. 2025Despite significant advancements in structural biology methods, studying the structure, dynamics and interaction mechanisms of protein and nucleic acid complexes remains a challenging process. This is illustrated by the ... -
Preparation and characterization of functionalized surfaces for desorption-ionization mass spectrometry
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2025)Datum obhajoby: 28. 3. 2025Structural proteomics combined with mass spectrometry, is a rapidly evolving scientific discipline that focuses on the characterization of the three-dimensional structures of proteins, as well as their dynamics. However, ... -
The Vanishing Agent: Analysis of Causality in Biology
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2025)Datum obhajoby: 27. 3. 2025The Vanishing Agent: Analysis of Causality in Biology Summary I am trying to show how the autonomy of both biology, and the concept of organisms it uses, depend on the notion of causality. The physicalist takeover of biology ... -
Biodiversity and speciation in moss-inhabiting flea beetles (Coleoptera: Chrysomelidae: Alticini)
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2025)Datum obhajoby: 27. 3. 2025Abstract. Flightless insects are both a striking evolutionary model, and a source of unknown species diversity challenging to taxonomists. This thesis explores the evolution, biodiversity, and biogeography of moss-inhabiting ... -
Early evolution of land plants in the Silurian with special respect to the Prague Basin (Barrandian area, Czech Republic)
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2025)Datum obhajoby: 26. 3. 2025This dissertation focuses on the study of fossil evidence of terrestrial plants from the Silurian period, found in the sediments of the Prague Basin - a site of global significance for documenting the evolution of early ... -
Genomická architektura a molekulární mechanismy hybridní sterility myši.
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2021)Datum obhajoby: 11. 2. 2021Hybrid sterility is one of the reproductive isolation mechanisms restricting gene flow between the related species and leading to speciation. PR domain containing 9 (Prdm9), the only known vertebrate hybrid sterility gene, ... -
The effect of thermogenic stimuli on the immune system
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2025)Datum obhajoby: 25. 3. 2025Organisms possess sophisticated defense mechanisms to maintain homeostasis and combat threats. The immune system plays a pivotal role in this defense, recognizing and responding to threats from both the internal and external ... -
Joseph Bernt v kontextu utváření Staatsarzneikunde
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2025)Datum obhajoby: 25. 3. 2025The presented dissertation focuses on two interconnected topics. First, it examines Joseph Bernt (1770-1842), a native of Litoměřice and a professor of so-called state medicine, who served at both the Vienna and Prague ... -
Maintenance of genome integrity in early development, aging and diseases
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2025)Datum obhajoby: 24. 3. 2025Maintenance of genome integrity includes different pathways, such as control of the cell cycle, checkpoint signaling, and DNA repair pathways, which are essential for normal cell division, healthy aging of organisms, and ... -
Analýza střevní mikrobioty v různých částech trávicího traktu u vybraných zástupců rodu Mus z pohledu životního stylu, genetické příbuznosti a sociálních vztahů
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2025)Datum obhajoby: 24. 3. 2025The vertebrate gastrointestinal microbiota (GM) affects host health, physiology, and shapes sig- nificantly its host's phenotype, including fitness-related traits. Conversely, GM composition is shaped by host genetics, but ... -
Učitelské strategie rozvoje mapových dovedností ve výuce zeměpisu
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2025)Datum obhajoby: 24. 3. 2025Developing map skills is a key part of geography education as it enables students to better understand spatial relationships and to analyse or interpret geographical information. This dissertation focuses on teachers' ... -
Predictors and correlates of altruism in humans from the evolutionary viewpoint
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2025)Datum obhajoby: 24. 3. 2025Predictors and correlates of altruism in humans from the evolutionary viewpoint Julie Nekola Nováková ABSTRACT Altruism has long presented an evolutionary enigma, as this behavior - where an individual helps another at its ... -
Pořadí narození jako faktor ovlivňující člověka
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2025)Datum obhajoby: 24. 3. 20251 Abstract Birth order plays a significant role in individual development, influencing personality traits, educational achievements, and reproductive strategies. This dissertation examines sibling positions within family ... -
New deazapurine nucleobases, nucleosides and nucleotides as potential cytostatics or CD73 inhibitors
Výsledek obhajoby: OBHÁJENO(Univerzita Karlova, Přírodovědecká fakulta, 2025)Datum obhajoby: 21. 3. 20251 ABSTRACT This thesis aims to regulate the role of adenosine in various cancers by modulating the activity of two different molecular targets. In the first part of my thesis, I describe the synthesis of a larger library ...