The aim of the presented thesis is to introduce modern procedures of histopathological analysis including immunohistochemical and molecular methods for the diagnosis, prevention and innovative surgical approaches for the ...

A promising new smart scaffold with potential for clinical use was prepared during our experiments. The biocompatible, biodegradable, osteoconductive and also osteoinductive 3D scaffold contains 0.5% type I collagen and ...

New approaches for the treatment of SCI use advances in the fields of nanotechnology, biomaterial science and cell therapy. The results presented in this thesis showed that superparamagnetic iron oxide nanoparticles coated ...

Hypercapnia could be used in the treatment of critically ill patients with chronic hypoxia (cardio - pulmonary failure) as a prevention against the development of hypoxic pulmonary hypertension. This work showed the reason ...

Body cavity surgical procedures have been arising. The surgery is complex and often extending two hours on patiens with serious comorbidities and over 65 years of age. The major cavities are the thorax, abdomen and skull. ...

Acute gastroenteritis is one of the most frequent diseases in children worldwide and remains the main cause of childhood morbidity and mortality, particularly in developing countries. Each year as many as 1.5 million ...

Lipofuscin-like pigments are products of reactions involving free radical attack onto molecules with nucleophilic groups. They can be for med, for example, in the reactions between lipid peroxidation decomposition products, ...

The pathology of immune system can lead to immune disorders. Immunodeficencies are caused by insufficient or missing immune response. On the other hand, allergies and autoimmune disorders represent a consequence of wrong ...

Great progress has been achieved in the diagnostics and therapy of childhood acute lymphoblastic leukemia (ALL) during the last few decades and the permanent cure rate for children and adolescents has risen to nearly 90%. ...

Autoreferát Summary Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive diseases which are characterized by inadequate secretion of steroid hormones of the adrenal cortex. The most common type of CAH is ...

Oncolytic viruses are examined to serve as anticancer therapeutics. It is expected that in addition to direct oncolytic effect their action will also help eliciting a solid antitumor immunity. In presented series of ...

The aim of the study was to evaluate the effect of human immunodeficiency virus infection (HIV) and antiretroviral treatment on the retinal nerve fibre layer (RNFL). The RNFL hickness defined by standard parameters(TSNIT ...

Introduction The endothelial dysfunction and related corneal oedema with decreased transparency id still the main indication for keratoplasty. Method of posterior lamellar keratoplasty, which is popular in oftalmology in ...

Tissue engineering is a rapidly developing field, based on using scaffolds made from natural or synthetic materials in combination with cells and stimulating factors for the replacement of damaged or lost tissue. It is ...

121 9. Summárý Purpose: This study was designed to evaluate the role of interventional radiology in liver transplantation programme. The aim is to present our experience, technical outcomes and long-term clinical results ...

Cortical inhibitory interneurons play an important role in cortical neuronal circuits in physiological state and probably also in the etiopathogenesis of epilepsy. The first part of my research work was focused on calretinin ...

Summary: Bacteria from Burkholderia cepacia complex represent the most serious pathogens for patients with cystic fibrosis. Their severity is ca1,Ised by thei antibiotic resistance and ability to spread an1ong patients ...

Aortic, mitral and pulmonary valve replacement is routinely performed with reasonable clinical results. But the optimal substitute for the tricuspid valve remains controversial. Contemporary prostheses either mechanical ...

Cystic fibrosis is the most abundant inherited autosomal recessive disease in Caucasian population. Cystic fibrosis is caused by a dysfunction of a transport channel which is responsible for the transport of chloride ions ...

So far, the lymphoid to myeloid lineage switch during the treatment of B cell precursor acute lymphoblastic leukemia (BCP ALL) was identified only rarely in patients with the MLL gene rearrangement. We discovered a novel ...

Newborn screening for cystic fibrosis allows diagnosing patients with cystic fibrosis during asymptomatic stage of their disease or when the symptoms had not fully developed. Due to early diagnosis, patients with cystic ...

Lyme disease (LD) and human granulocytic anaplasmosis (HGA) are anthropozoonoses that occur in the same geographical areas and are transmitted to humans by the same species of ticks of the genus Ixodes. While the extracellular ...

Development and evaluation of new cementless revision acetabular components for total hip arthroplasty / type TC / Objective: The aim of the clinical part of the study was to introduce a new revision oval cup type TC, and ...

Cílem této studie bylo ověřit platnost Harmanovy teorie stárnutí, založené na působen í volných ra dikálů, na nových modelech stárnutí rostlin a kvasinek, jelikož tyto organizmy byly nedávno přijaty mezinárodní komunitou ...

Epilepsy is one of the most common neurological disorders with prevalence 0,5 to 1 %. Considerable number of patients (particularly children) suffers from intractable focal epilepsy caused by focal cortical dysplasia (FCD) ...

The prevention and treatment of obesity is a major problem of health care systems in affluent societies. Metabolism of adipose tissue belongs to the therapeutical targets, since accumulation of adipose tissue is the basis ...

Distal radius fractures are the most common types of break to the arm bones. Conservative treatment in unstable fracture types cannot guarantee healing of the bones in a correct anatomical position. Locking plate osteosynthesis ...

Background: Breastfeeding is supposed to exert long-term protection of the infant from the development of civilisation diseases later in life. Adiponectin, leptin and AFABP are candidate proteins in nutritional programming ...

The inner circadian timekeeping system rules all physiological proccesses that repeat in our body regularly every day. This system works at many different levels, from the molecular level to the level of complex behavior. ...

Hearing loss is the most common sensory deficit and it affects 1 of 300 newborns. Genetic causes are responsible for 50-75% of cases. The most common cause of hereditary hearing loss (HHL) are mutations of GJB2 gene, which ...