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Histopatologické prediktory závažnosti klinického průběhu a rozvoje chirurgických komplikací u dětí se zánětlivými střevními onemocněními
Defence status: DEFENDED(Univerzita Karlova, 2. lékařská fakulta, 2021)Date of defense: 18. 3. 2021The aim of the presented thesis is to summarize a benefit and limitations of histopathological assessment of bioptic samples for diagnostics and prediction of complicated course of the disease in children with inflammatory ... -
Genetické vyšetření u pacientů s hypertrofickou kardiomyopatií
Defence status: DEFENDED(Univerzita Karlova, 2. lékařská fakulta, 2021)Date of defense: 25. 1. 2021Introduction: Hypertrophic cardiomyopathy (HCM) is characterised by marked heterogeneity both in phenotype and genotype. One of the main objectives in medical care is early HCM diagnosis and prevention of cardiovascular ... -
Patogenetické mechanismy imunitní dysregulace a hematopoetických onemocnění
Defence status: DEFENDED(Univerzita Karlova, 2. lékařská fakulta, 2022)Date of defense: 13. 9. 2022Pathogenetic mechanisms of immune dysregulation and hematopoietic disorders Abstract The aim of my work was to introduce whole exome sequencing (WES) and a routine algorithm for data analysis in pediatric patients with ... -
Wnt/beta-catenin and mTOR signaling in regulation of T-cell phenotype and cytotoxic activity for adoptive cellular immunotherapy of cancer
Defence status: DEFENDED(Univerzita Karlova, 2. lékařská fakulta, 2020)Date of defense: 4. 9. 2020The adoptive cellular immunotherapy (ACI) based on ex vivo produced T cells is a modern treatment modality of cancer. However, the ex vivo production of T cells with high therapeutic efficacy is far to be well established. ... -
Souvislosti vrozených pohybových vzorců reflexní lokomoce a ventilace u dětských pacientů s chronickým respiračním onemocněním
Defence status: DEFENDED(Univerzita Karlova, 2. lékařská fakulta, 2023)Date of defense: 19. 10. 2023Reflex locomotion according to Professor Vojta (VRL) is based on the activation of complex motor patterns from certain defined positions with stimulation of the so-called trigger zones, located on the human's body. It is ... -
Jednorázová asociační úloha jako základní biologický model epizodické paměti
Defence status: DEFENDED(Univerzita Karlova, 2. lékařská fakulta, 2023)Date of defense: 11. 12. 2023One-trial association task as a basic biological model of episodic memory in rats Abstract A very important structure in the animal and human brain is the hippocampus. The study one of its many functions, episodic memory, ... -
Vliv modifikace extracelulární matrix na změnu struktury a regeneraci nervové tkáně
Defence status: DEFENDED(Univerzita Karlova, 2. lékařská fakulta, 2022)Date of defense: 12. 9. 2022Regeneration and structural changes of the nerve tissue after the extracellular matrix modification. Abstract ECM modification may contribute to changes in nerve tissue plasticity. Therefore, 4- methylubulliferone is used ... -
Interactions of skin and stem cells with polymer nanofibres for construction of skin substitutes
Defence status: DEFENDED(Univerzita Karlova, 2. lékařská fakulta, 2022)Date of defense: 22. 9. 2022The skin is the largest organ of a human body with a crucial role in the maintenance of homeostasis; therefore any extensive skin injury leads to severe complications. Since the application of auto-, allo- and xeno-grafts ... -
Epileptogeneze u encefalitid sdružených s autoprotilátkami
Defence status: DEFENDED(Univerzita Karlova, 2. lékařská fakulta, 2020)Date of defense: 21. 9. 20209 Abstract The aim of this thesis is the role of neuronal antibodies in epileptogenesis. In the first phase of research we focused on 1) characteristics of epileptic seizures in patients with autoimmune encephalitis, 2) ... -
Kombinační farmakoterapie různých typů plicní hypertenze
Defence status: DEFENDED(Univerzita Karlova, 2. lékařská fakulta, 2023)Date of defense: 14. 9. 2023Pulmonary hypertension is a group of diseases characterized by increased mean pulmonary artery pressure. Especially in group 2, which is associated with heart disease and is the most prevalent of all types, and in group ... -
Early stages of neurodegenerative diseases and their diagnosis using experimental cognitive tests with a specific focus on spatial cognition
Defence status: DEFENDED(Univerzita Karlova, 2. lékařská fakulta, 2022)Date of defense: 19. 9. 2022Early stages of neurodegenerative diseases and their diagnosis using experimental cognitive tests with a specific focus on spatial navigation Abstract This dissertation thesis is focused on early and differential diagnosis ... -
Moderní biomateriály pro regeneraci pojivových tkání
Defence status: DEFENDED(Univerzita Karlova, 2. lékařská fakulta, 2022)Date of defense: 6. 9. 2022Connective tissues are characterized by significant volume of extracellular matrix. Their main role is to provide a mechanical support and protection to other body organs. This thesis is focused on regeneration of bone, ... -
Biochemie a patobiochemie fylochinonu a menachinonů
Defence status: DEFENDED(Univerzita Karlova, 2. lékařská fakulta, 2020)Date of defense: 9. 11. 2020Vitamin K belongs to the family of fat-soluble vitamins, which is not determinated in clinical laboratories. It is a cofactor necessary for posttranslational γ-carboxylation of glutamyl residues in selected proteins such ... -
Natural biomaterials and mesenchymal stem cells in regeneration of spinal cord injury
Defence status: DEFENDED(Univerzita Karlova, 2. lékařská fakulta, 2019)Date of defense: 4. 3. 2019Spinal cord injury is a serious trauma and despite intensive research there is still no effective treatment for patients. The aim of this thesis is to study new possibilities of spinal cord injury therapy in animal models. ... -
Úloha metabolitů kyseliny arachidonové v regulaci krevního tlaku u experimentálních modelů ANGII-dependentní formy hypertenze
Defence status: DEFENDED(Univerzita Karlova, 2. lékařská fakulta, 2020)Date of defense: 24. 9. 2020Introduction: Two major product groups originate from the arachidonic acid metabolic pathway of cytochromes P450: epoxyeicosatrienoic acid (EETs) and 19 and 20-hydroxyeicosatetraenoic acid (19- and 20-HETE). These metabolites ... -
Využití kmenových buněk v léčbě amyotrofické laterální sklerózy
Defence status: DEFENDED(Univerzita Karlova, 2. lékařská fakulta, 2020)Date of defense: 3. 2. 2020Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease caused by degradation of motoneurons (MN). No effective treatment is currently available. Cellular therapy is considered to be a promising experimental ... -
Vliv časné léčby na psychomotorický vývoj u dětí s epileptickou encefalopatií
Defence status: DEFENDED(Univerzita Karlova, 2. lékařská fakulta, 2019)Date of defense: 4. 3. 2019Children with focal intractable epilepsy caused by MCD, FCD and TSC are in a high risk of development of cognitive delay, as a result of both drug resistant epilepsy and genetically determined abnormal structure of the ... -
Vytvoření a vedení neuroepidemiologické studie kognitivního stárnutí a mírné kognitivní poruchy (MCI), s důrazem na vliv faktorů životního stylu a prevenci
Defence status: DEFENDED(Univerzita Karlova, 2. lékařská fakulta, 2020)Date of defense: 13. 7. 2020Identifikační záznam: SHEARDOVA, Kateřina. The Design and Conduct of the study of aging, and MCI within International Clinical Research Centre in Brno, Czech Republic, with the emphasis on the life style factors. Praha, ... -
Perineurální šíření pánevních nádorů: mechanismus a diagnostika
Defence status: DEFENDED(Univerzita Karlova, 2. lékařská fakulta, 2021)Date of defense: 20. 9. 2021Perineural spread of pelvic tumors mechanism and diagnosis Abstract Neoplastic lumbosacral plexopathies are infrequent affections of the lumbosacral plexus. Cases with minimal or non-specific finding on imaging can be ... -
Přínos jednotlivých intraoperačních elektrofyziologických metod u dětských epileptochirurgických pacientů
Defence status: DEFENDED(Univerzita Karlova, 2. lékařská fakulta, 2020)Date of defense: 31. 8. 2020Epilepsy, as the most common chronic neurological disease, affects a significant part of population (0.5-1%). Drug resistant epilepsy has a significant negative effect on the quality of life, psychiatric comorbidities, ...
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