Vliv hypoxie a tlakového přetížení na G proteiny řízenou signalizaci v myokardu potkana

Hrbasová, Markéta

Influence of chronic hypoxia and pressure overload on G protein - mediated signalization in myocard of rats

dc.contributor.advisor	Svoboda, Petr
dc.creator	Hrbasová, Markéta
dc.date.accessioned	2025-02-06T11:34:11Z
dc.date.available	2025-02-06T11:34:11Z
dc.date.issued	2007
dc.identifier.uri	http://hdl.handle.net/20.500.11956/196359
dc.description.abstract	Conclusion Hypertophy In conclusion, our present study revealed that sustained pressure overload applied in newbom rats does not influence distribution of G proteins in immature myocardium, but appreciably reduces the content of G.clL and increases the level of Gocr proteins in myocardium from adult rats. The finding of distinct regulation of the long and short G,o isoforms during normal development and during pathological cardiac growth strongly suppořts the notion about unequal behavior and possibly function of these proteins [95]. Similar decrease in AC activity determined under diffbrent stimulation conditions together with a lower ability of Mn2* to stimulate AC activity suggests that it is a function of AC catalytic subunit thaÍ is primarily impaired in pressure overload-induced cardiomegaly. Derangalent of tlp AC signaling is reflected by cardiac dysfunction. These data might be of potentiď rclevance to certain types of human congenital heart defects associarď lvith irrcreased LV pressure, such as Severe coarctation ofthe aorta or aortic stenosis Hypxia In conclusion. adaptation ofrats to IHA hypoxia led to increased localization of G"cr-L in the cytosolic fractions and it was associated with reduced bioactivity of membrane-bound Gsa protein and lower AC activity especially in RV. These changes may...	en_US
dc.language	Čeština	cs_CZ
dc.language.iso	cs_CZ
dc.publisher	Univerzita Karlova, Přírodovědecká fakulta	cs_CZ
dc.title	Vliv hypoxie a tlakového přetížení na G proteiny řízenou signalizaci v myokardu potkana	cs_CZ
dc.type	dizertační práce	cs_CZ
dcterms.created	2007
dcterms.dateAccepted	2007-05-21
dc.description.department	Katedra biochemie	cs_CZ
dc.description.department	Department of Biochemistry	en_US
dc.description.faculty	Přírodovědecká fakulta	cs_CZ
dc.description.faculty	Faculty of Science	en_US
dc.identifier.repId	112499
dc.title.translated	Influence of chronic hypoxia and pressure overload on G protein - mediated signalization in myocard of rats	en_US
dc.contributor.referee	Nováková, Olga
dc.contributor.referee	Perlík, František
thesis.degree.name	Ph.D.
thesis.degree.level	doktorské	cs_CZ
thesis.degree.discipline	Biochemie	cs_CZ
thesis.degree.program	Biochemistry	en_US
thesis.degree.program	Biochemie	cs_CZ
uk.thesis.type	dizertační práce	cs_CZ
uk.taxonomy.organization-cs	Přírodovědecká fakulta::Katedra biochemie	cs_CZ
uk.taxonomy.organization-en	Faculty of Science::Department of Biochemistry	en_US
uk.faculty-name.cs	Přírodovědecká fakulta	cs_CZ
uk.faculty-name.en	Faculty of Science	en_US
uk.faculty-abbr.cs	PřF	cs_CZ
uk.degree-discipline.cs	Biochemie	cs_CZ
uk.degree-program.cs	Biochemie	cs_CZ
uk.degree-program.en	Biochemistry	en_US
thesis.grade.cs	Prospěl/a	cs_CZ
thesis.grade.en	Pass	en_US
uk.abstract.en	Conclusion Hypertophy In conclusion, our present study revealed that sustained pressure overload applied in newbom rats does not influence distribution of G proteins in immature myocardium, but appreciably reduces the content of G.clL and increases the level of Gocr proteins in myocardium from adult rats. The finding of distinct regulation of the long and short G,o isoforms during normal development and during pathological cardiac growth strongly suppořts the notion about unequal behavior and possibly function of these proteins [95]. Similar decrease in AC activity determined under diffbrent stimulation conditions together with a lower ability of Mn2* to stimulate AC activity suggests that it is a function of AC catalytic subunit thaÍ is primarily impaired in pressure overload-induced cardiomegaly. Derangalent of tlp AC signaling is reflected by cardiac dysfunction. These data might be of potentiď rclevance to certain types of human congenital heart defects associarď lvith irrcreased LV pressure, such as Severe coarctation ofthe aorta or aortic stenosis Hypxia In conclusion. adaptation ofrats to IHA hypoxia led to increased localization of G"cr-L in the cytosolic fractions and it was associated with reduced bioactivity of membrane-bound Gsa protein and lower AC activity especially in RV. These changes may...	en_US
uk.file-availability	P
uk.grantor	Univerzita Karlova, Přírodovědecká fakulta, Katedra biochemie	cs_CZ
thesis.grade.code	P
uk.publication-place	Praha	cs_CZ
uk.embargo.reason	Dokument je přístupný pouze ve věcné databázi závěrečných prací v souladu s čl. 18a odst. 5 Studijního a zkušebního řádu Univerzity Karlovy v Praze.	cs
uk.embargo.reason	The document is accessible only in the physical database of theses in accordance with Article 18a (5) of the Code of Study and Examination.	en
uk.thesis.defenceStatus	O