2. lékařská fakulta: Recent submissions
Now showing items 41-60 of 1925
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Resynchronizace a prosynchronizace u trvalé kardiostimulace u dětí
Defence status: DEFENDED(Univerzita Karlova, 2. lékařská fakulta, 2016)Date of defense: 21. 1. 20161 Abstrakt Cíl: Zhodnocení dlouhodobých výsledků trvalé epikardiální stimulace a klinického vlivu elektromechanické dyssynchronie u trvalé kardiostimulace v dětském věku. Nalezení optimálních stimulačních míst k zamezení ... -
Tloušťka vrstvy nervových vláken sítnice u dětských pacientů s glaukomem měřená skenovací laserovou polarimetrií
Defence status: DEFENDED(Univerzita Karlova, 2. lékařská fakulta, 2016)Date of defense: 4. 10. 2016Martin Hložánek: Retinal nerve fiber layer thickness in pediatric glaucoma patients, measured by scanning laser polarimetry Abstract Introduction Glaucoma is the leading cause of irreversible blindness worldwide. It is ... -
Mechanismy regulace fetoplacentárního cévního řečiště při hypoxii
Defence status: DEFENDED(Univerzita Karlova, 2. lékařská fakulta, 2016)Date of defense: 22. 9. 2016The placenta and the lungs are the only organs that perform a function of blood oxygenation and have a common characteristic - vasoconstriction in response to acute hypoxia. Thus the reaction is in an opposite manner than ... -
Age and sex differences in GABAergic transmission in the substantia nigra pars reticulata in the rat
Defence status: DEFENDED(Univerzita Karlova, 2. lékařská fakulta, 2016)Date of defense: 2. 5. 2016Many experimental as well as clinical studies have shown that subcortical neuronal circuitries including the anterior part of the substantia nigra pars reticulata (SNR) are closely involved in the control of seizures ... -
Molekulární mechanismy karcinogeneze u karcinomu ledviny
Defence status: DEFENDED(Univerzita Karlova, 2. lékařská fakulta, 2016)Date of defense: 5. 9. 2016The receptor for advanced glycation end products (RAGE), soluble RAGE (sRAGE) and its ligands are involved in the pathogenesis of cancer. Glyoxalase I (GLO1) is an enzyme which detoxifies advanced glycation end product ... -
Localization and characterization of binding sites for Ca2+ binding proteins and phosphatidylinositol phosphates on intracellular termini of TRP channels
Defence status: DEFENDED(Univerzita Karlova, 2. lékařská fakulta, 2016)Date of defense: 29. 9. 2016This dissertation concerns with characterization of binding sites for calcium binding protein S100A1 and phosphatidylinositol phosphates on intracellular regions of transient receptor potential channels (TRPs), particular ... -
Asociačná štúdia s génom ADA a detailná charakterizácia dvoch chromozomálnych prestavieb u autizmu
Defence status: DEFENDED(Univerzita Karlova, 2. lékařská fakulta, 2009)Date of defense: 22. 10. 2009Autism affects up to 1/150 children and represents therefore a serious social problem. It is a complex disorder with a clearly documented genetic component, but so far unexplained aetiology, which is currently a subject ... -
Studium modulace rekombinativních a nativních NMDA receptorů fyzikálními a chemickými faktory
Defence status: DEFENDED(Univerzita Karlova, 2. lékařská fakulta, 2009)Date of defense: 21. 9. 2009Excitatory synaptic transmission in mammalian CNS is mostly mediated by ionotropic glutamate receptors. NMDA receptors, one of three subclasses of this ligand-activated ion channels family, are involved in memory formation ... -
Aspekty identifikace pacientů s primární ciliární dyskinezí
Defence status: DEFENDED(Univerzita Karlova, 2. lékařská fakulta, 2016)Date of defense: 15. 9. 2016Primary ciliary dyskinesia (PCD) is a rare but underdiagnosed genetic disease. This innate disorder of motile cilia causes a non-functional mucociliary clearance which is the main reason for a clinical picture of recurrent ... -
Ovlivnění kvality střevní stěny a reaktivita gastrointestinálního traktu na infekci Clostridium difficile
Defence status: DEFENDED(Univerzita Karlova, 2. lékařská fakulta, 2016)Date of defense: 19. 5. 2016Introduction Infections caused by C. difficile (CDI) are a serious complication of an antimicrobial treatment. Problems of this disease becomes more and more important due to the occurrence of new highly virulent strains ... -
Hodnocení ošetření zubu Er:YAG laserem ve srovnání s ostatními preparačními metodami
Defence status: DEFENDED(Univerzita Karlova, 2. lékařská fakulta, 2016)Date of defense: 13. 12. 2016Er: YAG laser is a new method of preparation that promises gentler and more accurate dental treatment. Its specific characteristics is large absorption of the beam in the water and a small absorption in the tissue without ... -
Aktivita katepsinu B u pacientů s karcinomem močového měchýře
Defence status: DEFENDED(Univerzita Karlova, 2. lékařská fakulta, 2016)Date of defense: 5. 9. 2016Bladder cancer is the most common malignant neoplasm of the urogenital tract. Of non- invasive diagnostic methods in clinical practice normally only is used cytology to its limits. While there are several commercially ... -
Charakterizace vazebných míst na intracelulárních koncích TRPC6 receptoru pro kalmodulin a S100A1
Defence status: DEFENDED(Univerzita Karlova, 2. lékařská fakulta, 2016)Date of defense: 29. 9. 2016Identification of the binding sites on transient receptor potential cation channel TRPC6 for Calmodulin and S100A1 The TRP (transient receptor potential) group of ion channels represents a large subset of membrane receptors. ... -
Optimizing Arterial Spin Labeling MRI for the diagnosis and monitoring of brain diseases
Defence status: DEFENDED(Univerzita Karlova, 2. lékařská fakulta, 2025)Date of defense: 2. 10. 2025Perfusion imaging is a medical diagnostic method that indicates the passage of blood through organs and tissues; this method is currently gaining more and more applications in clinical diagnostics and research. Perfusion ... -
Využití technik difuzního MR zobrazení v diagnostice nádorů mozku
Defence status: DEFENDED(Univerzita Karlova, 2. lékařská fakulta, 2025)Date of defense: 2. 10. 2025Use of diffusion MR techniques in diagnosis of brain tumors Abstract Diffusion magnetic resonance imaging represents a non-invasive method for analyzing brain tissue microstructure and tumor classification. The first part ... -
Výsledky léčby pacientů s diabetes mellitus v České republice a hypoglykemie jako jeden z ovlivňujících faktorů
Date of defense: 9. 10. 2025 -
Možnosti využití expertních systémů a 3D matematického modelování při léčbě cyst maxillofaciální oblasti
Defence status: DEFENDED(Univerzita Karlova, 2. lékařská fakulta, 2016)Date of defense: 28. 6. 2016Dentistry and medicine as part of empirical sciences, need to constantly develop in scientific field since the tasks it is facing today were unthinkable to solve few decades ago. Hence, dentistry is calling a greater ... -
Tissue pathology in relapse of talipes equinovarus congenitus (clubfoot) and the investigation of potential therapeutic approaches
Defence status: DEFENDED(Univerzita Karlova, 2. lékařská fakulta, 2025)Date of defense: 25. 9. 2025Tissue pathology in relapse of talipes equinovarus congenitus (clubfoot) and the investigation of potential therapeutic approaches Abstract Idiopathic talipes equinovarus (clubfoot) is one of the most common congenital ... -
Volná cirkulující DNA dárce jako marker pro sledování rejekce štěpu po transplantaci plic
Defence status: DEFENDED(Univerzita Karlova, 2. lékařská fakulta, 2025)Date of defense: 25. 9. 2025Lung transplantation is a dynamically developing therapeutic method indicated for the end- stages lung diseases of parenchymal or vascular origin. Despite significant advances in the field, long-term survival of lung ...