Effect of probiotics on immunoregulatory mechanisms in the intestine: from experiment to clinics

Kokešová, Alena

Účinek probiotik na imunoregulační mechanismus ve střevě: od pokusů ke klinické praxi

dc.contributor.advisor	Pelouch, Václav
dc.creator	Kokešová, Alena
dc.date.accessioned	2025-04-16T07:17:15Z
dc.date.available	2025-04-16T07:17:15Z
dc.date.issued	2006
dc.identifier.uri	http://hdl.handle.net/20.500.11956/197827
dc.description.abstract	Probiotics are defined as live cultures of micro-organisms administered orally and acting beneficially on host health. They inf1uence favourably both development and stability of the microf1ora, inhibit colonization by pathogens, inf1uence the mucosal barrier by their trophic effect on intestinal epithelium and stimulate both specific and non-specific components of the immune system, moreover, they may well replace antibiotics whose resistance is steadily increasing (Kalliomaki et a/. 2003). After a genetic manipulation, the commensal and probiotic strains could be used as vectors for clinica\Jy important molecules and for their preventive and therapeutic mucosal application (Seegers et a/. 2002). Orally administered probiotic bacteria are expected to survive the passage through stomach and colonize intestinal mucosal surfaces even if it were only for a short period. In addition to bacterial strains Lactobacillus and Bifidobacter, also some non-pathogenic strains of Escherichia coli (E.coli) proved suitable for this purpose. It was shown that colonization of new-boms with a non-pathogenic strain of E. coti 083 stimulated local and systemic humoural and cellular immune responses and reduced the number of pathogens (Cukrowska et al. 2002; Lodinová-Žádníková et a/.1991). It was found recently, that repeated...	en_US
dc.description.abstract	Účinek probiotik na imunoregulační mechanismus ve střevě: od pokusů ke klinické praxi Powered by TCPDF (www.tcpdf.org)	cs_CZ
dc.language	English	cs_CZ
dc.language.iso	en_US
dc.publisher	Univerzita Karlova, 2. lékařská fakulta	cs_CZ
dc.title	Effect of probiotics on immunoregulatory mechanisms in the intestine: from experiment to clinics	en_US
dc.type	dizertační práce	cs_CZ
dcterms.created	2006
dcterms.dateAccepted	2006-09-25
dc.description.department	Ústav lékařské chemie a klinické biochemie	cs_CZ
dc.description.department	Department of Medical Chemistry and Clinical Biochemistry	en_US
dc.description.faculty	Second Faculty of Medicine	en_US
dc.description.faculty	2. lékařská fakulta	cs_CZ
dc.identifier.repId	140035
dc.title.translated	Účinek probiotik na imunoregulační mechanismus ve střevě: od pokusů ke klinické praxi	cs_CZ
dc.contributor.referee	Prokešová, Ludmila
dc.contributor.referee	Mareš, Jan
dc.contributor.referee	Nevoral, Jiří
thesis.degree.name	Ph.D.
thesis.degree.level	doktorské	cs_CZ
thesis.degree.discipline	FYZIOLOGIE A PATOFYZIOLOGIE CLOVEKA	cs_CZ
thesis.degree.program	Human Physiology and Pathophysiology	en_US
thesis.degree.program	Fyziologie a patofyziologie člověka	cs_CZ
uk.thesis.type	dizertační práce	cs_CZ
uk.taxonomy.organization-cs	2. lékařská fakulta::Ústav lékařské chemie a klinické biochemie	cs_CZ
uk.taxonomy.organization-en	Second Faculty of Medicine::Department of Medical Chemistry and Clinical Biochemistry	en_US
uk.faculty-name.cs	2. lékařská fakulta	cs_CZ
uk.faculty-name.en	Second Faculty of Medicine	en_US
uk.faculty-abbr.cs	2.LF	cs_CZ
uk.degree-discipline.cs	FYZIOLOGIE A PATOFYZIOLOGIE CLOVEKA	cs_CZ
uk.degree-program.cs	Fyziologie a patofyziologie člověka	cs_CZ
uk.degree-program.en	Human Physiology and Pathophysiology	en_US
thesis.grade.cs	Prospěl/a	cs_CZ
thesis.grade.en	Pass	en_US
uk.abstract.cs	Účinek probiotik na imunoregulační mechanismus ve střevě: od pokusů ke klinické praxi Powered by TCPDF (www.tcpdf.org)	cs_CZ
uk.abstract.en	Probiotics are defined as live cultures of micro-organisms administered orally and acting beneficially on host health. They inf1uence favourably both development and stability of the microf1ora, inhibit colonization by pathogens, inf1uence the mucosal barrier by their trophic effect on intestinal epithelium and stimulate both specific and non-specific components of the immune system, moreover, they may well replace antibiotics whose resistance is steadily increasing (Kalliomaki et a/. 2003). After a genetic manipulation, the commensal and probiotic strains could be used as vectors for clinica\Jy important molecules and for their preventive and therapeutic mucosal application (Seegers et a/. 2002). Orally administered probiotic bacteria are expected to survive the passage through stomach and colonize intestinal mucosal surfaces even if it were only for a short period. In addition to bacterial strains Lactobacillus and Bifidobacter, also some non-pathogenic strains of Escherichia coli (E.coli) proved suitable for this purpose. It was shown that colonization of new-boms with a non-pathogenic strain of E. coti 083 stimulated local and systemic humoural and cellular immune responses and reduced the number of pathogens (Cukrowska et al. 2002; Lodinová-Žádníková et a/.1991). It was found recently, that repeated...	en_US
uk.file-availability	V
uk.grantor	Univerzita Karlova, 2. lékařská fakulta, Ústav lékařské chemie a klinické biochemie	cs_CZ
thesis.grade.code	P
dc.contributor.consultant	Tlaskalová - Hogenová, Helena
uk.publication-place	Praha	cs_CZ
uk.thesis.defenceStatus	O