Sledování strukturálních změn na mozku po facilitační fyzioterapii u lidí s roztroušenou sklerózou

Abstract

The main objective: The aim of this work is to determine whether lesion load changes after two months of ambulatory physiotherapy based on neurophysiology, whether these changes correlate with clinical outcomes and persist for two months after the end of the program. Methods: This work analyzes the data collected in the study "Neuroproprioceptive" Facilitation, Inhibition "and Brain Plasticity (NEFAI)", registered under the number NCT04355663. Patients with multiple sclerosis (MS) were randomly divided into 2 groups in 2015 and 2017. Each group underwent a different type of outpatient physiotherapy for neuroproprioceptive "facilitation, inhibition", so-called neurophysiological therapy (further in text referred as facilitation therapy) (1 hour twice a week, for a total of 16 therapies in 2 months). The first group underwent therapy using Motor Activating Therapy Programs (MPAT), the second Vojta's reflex therapy (VRL). The entry criteria were a clear diagnosis of MS, the presence of spastic paresis, a stable clinical picture, no changes in therapy in the last 3 months (stabilized state), an Expanded Disability Status Score (EDSS) of maximum values of 7.5. Exclusion criteria were other neurological diagnoses and conditions that prevent movement and all 3 visits were not met (before the start of the...

The main objective: The aim of this work is to determine whether lesion load changes after two months of ambulatory physiotherapy based on neurophysiology, whether these changes correlate with clinical outcomes and persist for two months after the end of the program. Methods: This work analyzes the data collected in the study "Neuroproprioceptive" Facilitation, Inhibition "and Brain Plasticity (NEFAI)", registered under the number NCT04355663. Patients with multiple sclerosis (MS) were randomly divided into 2 groups in 2015 and 2017. Each group underwent a different type of outpatient physiotherapy for neuroproprioceptive "facilitation, inhibition", so-called neurophysiological therapy (further in text referred as facilitation therapy) (1 hour twice a week, for a total of 16 therapies in 2 months). The first group underwent therapy using Motor Activating Therapy Programs (MPAT), the second Vojta's reflex therapy (VRL). The entry criteria were a clear diagnosis of MS, the presence of spastic paresis, a stable clinical picture, no changes in therapy in the last 3 months (stabilized state), an Expanded Disability Status Score (EDSS) of maximum values of 7.5. Exclusion criteria were other neurological diagnoses and conditions that prevent movement and all 3 visits were not met (before the start of the...