Korelace intrakraniálního tlaku a dalších vyšetřovaných parametrů u kontuzí mozku

Abstract

Patients with a brain injury must overcome a central neurological insult and a systematic metabolic response. The systematic response includes hypermetabolism, hypercatabolism, altered vascular permeability, increased hormone and cytokine release, altered gastric emptying, altered mineral metabolism and altered immune status. This response may initiate mechanisms which lead to secondary brain injury and may adversely affect the function of other organs. Last two decades have improved our knowledge of pathophysiology in patients with primary and secondary brain injury including traumatic contusions. In a moment of injury, primary brain injury which is traumatic contusion can not be therapeutically prevented it can only have a preventive effect. Secondary brain injury can be therapeutically affected although both types of injuries have common pathophysiological signs of disturbed metabolism on cells and subcellular level. Research methods based on molecular biology opens a new zone of research reaction of central neurological system for trauma or ischemia with effort to get involved immediately at the beginning of developing adverse pathophysiological cascade leading to a death of neurotic cell. The brain contusion is a primary centre of brain injury with anatomic changes which can be graphically proved. In...

Autor se ve své práci zabývá centrálním neurologickým postižením a systémovou metabolickou reakcí u pacientů po poranění mozku. Systémová odpověď zahrnuje hypermetabolizmus, hyperkatabolizmus, změněnou cévní prostupnost, rostoucí uvolnění hormonů a cytokinů, změněné gastrální vyprazdňování, minerální a glukózový metabolizmus a imunitní stav. Autor zahrnul do studie 51 pacientů s kontuzí mozku se vstupní poruchou vědomí.